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Prednisone & Weight Gain (The Studies) Many studies have been conducted to evaluate the side effect profile of prednisone and similar corticosteroid medicationsand see if any weight gains are observed by a certain body mass index (BMI). Some of these studies are summarized below:A 2004 Cochrane review conducted by the United Kingdom's Royal College of Obstetricians and Gynecologists showed a high risk of weight gain associated with short doses of prednisone. This increased weight gain was seen in women taking 10mg every 2-3 times per day (in excess of the recommended 10-15 mg given to normal healthy postmenopausal women), steroids in ent. The highest weight gain occurred with the shortest (5mg) dose, and lowest was with the longest (10mg), prednisone.A 2003 meta-analysis of 25 studies showed that prednisone had a moderate to high risk of weight gain, and that weight loss was associated with a 5% to 10% increase in BMD.A 2001 meta analysis of 15 randomized controlled trials found that in women taking prednisone the risk of gaining weight was higher than in non-users, and the amount of weight regain was higher as well, oral corticosteroids bnf. No additional weight gain was seen with weight loss.A 2009 meta-analysis by the American Journal of Clinical Nutrition found a moderate to high risk of weight gain associated with both short- and long-term use of prednisone. A study of 15,823 women found that more than 20% of the women gained 5 percent to 10 percent of their body weight while on the medication, and the most common increase in BMD was 2%.A 2003 meta-analysis conducted by the Centers for Disease Control and Prevention (CDC) on the health effects of the synthetic estradiol analogs dihydrogestradiol and 19-nor-19-dihydro-beta-D-glucuronide found that these medications are associated with a increased risk of osteoporosis and bone loss, but did not suggest if weight gain or weight loss could be observed with these drugs.A 1994 study conducted by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) in collaboration with the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS, also NIH), found no differences in weight gain or weight loss between women taking prednisone and those not on the medication, prednisone.